How do you hope to fulfill that potential? The NSF CAREER Award not only funds a research project, but it also recognizes the potential of the recipient as a researcher, educator and leader in their field. Students interested in participating should email me at for more information. Undergraduate and graduate students will be educated and trained on interdisciplinary (materials and medicine) bone research. The education and outreach activities in this project will build a pipeline to include more students in STEM fields. Will undergraduate or graduate students contribute to this research? How? The new knowledge about bone will also provide inspiration for the design of more robust manmade materials enable the advancement in biomedical materials be extended to the research of other natural biocomposites and significantly impact the broad range of applications in transportation, buildings, defense, biomedicine and energy. There are 10.2 million American people aged 50 and over with osteoporosis, which may lead to an increased risk of fracture. How will advances in this area impact society?Ī deeper understanding of bone can provide insights to fracture prediction and benefit the aging population and people with bone disorders. Finally, the peri-implant bone adaptation will be investigated in terms of its extrinsic morphology and intrinsic properties. Then in cortical bone and trabecular bone, the composition-structure-property across multiple length scales will be determined, respectively. We will first develop correlative microscopy techniques to characterize composition, structure, and properties for ultrastructure and microstructure of bone. The central hypothesis is that the bulk properties of bone (strength, toughness, adaptation) are related to the composition, structure and properties in its microscale structures (cement line and sub-lamellae) and nanoscale ultrastructure (mineralized collagen fibril and extrafibrillar matrix). The research objective of this project is to determine the composition-structure-property relationships in bone at multiple length scales, using integrated experiments and models. However, the structures in the bone at the sub-micron and nanoscales are still not well understood. It is strong and tough, yet lightweight, which can be attributed to its hierarchical structures - also known as structures at multiple length scales. What do you want to understand or solve through this project?īone is a typical mineralized biological tissue that exhibits superior mechanical properties. Jing Du, assistant professor of mechanical engineering at Penn State, earned a five-year, $552,606 NSF CAREER Award for a project titled “ Structures and Properties of Bone at Multiple Length Scales.” Jing Du, assistant professor of mechanical engineering at Penn State, earned a five-year, $552,606 NSF CAREER Award.
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